Study of the Effect of Eudragit RSPO on the Photostability of Venlafaxine in a Physical Mixture and in a Melt Form

The effect of Eudragit RSPO on the photostability venlafaxine in a physical mixture and as melt was studied. A validated ultra-high-performance liquid chromatography mass spectrometry method used to determine content alongside degradation products. most likely structures products were determined by spectrometry. samples evaluated before after exposure ultraviolet differential scanning calorimetry electron microscopy. kinetic parameters decomposition form calculated comparable those an active pharmaceutical ingredient. results indicate that process is more than three times slower venlafaxine–eudragit its with eudragit pure form. strong photoprotective nature tested polymer against also confirmed